Dr. Richard Schlegel, M.D., Ph.D.
Chair, Department of Pathology,
Professor of Pathology, Oncology,
Microbiology and Immunology, and Obstetrics and Gynecology
"Translating HPV and cell reprogramming research into clinical applications"
Thursday September 27, 2012
Green Auditorium, Scott Hall
HPV causes almost all incidences of cervical cancer, which is the second-leading cause of cancer deaths in women worldwide. Dr. Schlegel’s laboratory is currently developing, with grants from the Bill and Melinda Gates Foundation and the National Institutes of Health (NIH), second- and third-generation vaccines that could be used to prevent HPV and decrease the incidence of HPV in the developing world, where almost all deaths from cervical cancer occur.
Beginning in 1980, Dr. Schlegel was an investigator, then a senior investigator at the National Cancer Institute (NCI), and later served as Chief of the Cell Regulation and Transformation Section in the Laboratory of Tumor Virus Biology at NCI. In 1990, he joined GUMC as an Associate Professor in the Department of Pathology, and became Chair of that department in 2003. He serves on the editorial board of the journal Virology and serves as a permanent member of the NIH Virology study section.
He received his M.D. and Ph.D. degrees from Northwestern University Medical School, and was a resident and post-doctoral fellow at Harvard Medical School (Brigham Hospital) in the fields of Pathology and Virology.
Building from his work on the first-generation HPV vaccine, the second- and third-generation vaccines are being based upon a GST-L1 fusion protein expressed in bacteria. Appending GST to L1—the major component in the first generation vaccine— allows for rapid purification of the vaccine, as well as stabilizing its protein conformation.
Previous Keynote Speakers
2010: Joseph Thornton, Ph.D.
2009: Sean J. Morrison, Ph.D.
2007: Edward Ziff, Ph.D.
2006: Joseph Avruch, M.D.
2005: Arthur Horwich, M.D.
2004: Harvey Lodish Ph.D.